Abstract: Abstract Objective To observe the improvement on contrast induced acute kidney injury (CIAKI) before coronary angiography with different doses of atorvastatin combined with probucol. Methods 98 cases admitted for coronary angiography (CAG) or percutaneous coronary stent implantation(PCI) were randomly divided into three groups：Standard treatment group: atorvastatin 20mg qn and Probucol 0.25g/tid, no enhancement before angiography; Strengthen and combined treatment group: atorvastatin 40mg qn and Probucol 0.25g/tid, atorvastatin 40mg and Probucol 0.5g 2 hours were administered before the angiography; Intensive therapy group: atorvastatin 40mg qn, atorvastatin 40mg 2 hours were administered before the angiography. All patients were then evaluated 24 hours before and after the angiography procedure, and their blood urea nitrogen (BUN), serum creatinine (Scr),renin All items (renin ,AngII and aldosterone), and estimated glomerular filtration rate (eGFR) by MDRD method were tested. Results 1) The Scr of Standard treatment group was higher postoperatively than the preoperative value (P = 0.044), e GFR decreased significantly (P = 0.006); The BUN of Strengthen and combined treatment group (P <0.001) and Intensive therapy group (P = 0.029) were remarkably decreased postoperatively. There was no significant difference in Scr and e GFR. (2) The value of △ Scr (P = 0.02)and△ AngII (P = 0.04) in Strengthen and combined treatment group was higher , △ e GFR (P = 0.015) was reduced.（3）For the patients of mild to moderate renal function , The value of△ Scr (P = 0.025) and △ AngII (P = 0.031) in Strengthen and combined treatment group significantly increased , △ eGFR (P = 0.025) was reduced .Conclusion The combination of atorvastatin 40mg and Probucol 0.25 tid or one with atorvastatin 40mg before angiography could improve the CIAKI, however, the role of Strengthen and combined treatment group improved significantly. For the patients of mild to moderate renal function, Strengthen and combined treatment group could improve significantly.

Key words: Atorvastatin, Probucol, contrast induced acute kidney injury, Renin - angiotensin - aldosterone system.