Abstract: Abstract：Objective To compare the effects of postoperative analgesia with sufentanil or flurbiprofen on cellular immune function. Methods Forty-five ASA ⅠorⅡ patients undergoing cholecystectomy were randomly divided into three groups with 15cases each: groupⅠPCIA with sufentanil 2ug/ml; groupⅡ PCIA with sufentanil 0.75ug/ml+flurbiprofen 1mg/ml and groupⅢ PCIA with sufentanil 0.5ug/ml+flurbiprofen 1mg/ml. PCIA was started with background infusion rate 2 ml/h, blouse dose 0.5ml, lockout interval 5 min. VAS scores were measured at 4,24h and 48h after operation respectively. Blood samples were obtained from peripheral vein at before operation, and at 1,24,72h after operation for determination of the plasma levels of CD3+、CD4+ and CD8+ in lymphocyte. CD4+ /CD8+ ratio was calculated. Results VAS scores of groupⅢ were markedly higher than that of groupⅠand groupⅡin postoperative 4,24h and 48h (P<0.05). Before anesthesia, there were no significant difference in T Lymphocytic cell subpopulation (CD3+,CD4+,CD8+,CD4+/D8+), among three groups(P>0.05). The level of CD3+,CD4+ and CD4+/D8+ were all decreased at postoperative 1h and 24h in three groups compared with baseline value, while the level of CD3+,CD4+ and CD4+/D8+ in groupⅡand groupⅢ were increased compare with groupⅠ(P<0.05). Conclusions Flurbiprofen can improve the cellular immune function in the patients after cholecystectomy through reducing the consumption of sufentanil for PCIA.

Key words: Analgesia, Sufentanil, Flurbiprofen, Immune function