Abstract: Objective: To explore the changes of Th1/Th2 chemokines CXCL10、CCL22 and its clinical significance in the patient with Graves disease. Method: 76 outpatient with Graves disease in different stage of treatment were selected,including untreated group、remission、stable group and control group. We collected the datas including thyroid function、thyroid antibodys，as well as the level of serum CXCL10 and CCL22 detected by ELISA. Results: Serum CXCL10、CCL22 level were significantly increased in untreaded group（p<0.001）,after treatment CXCL10、CCL22 levels the ratio(CXCL10/CCL22) were significantly decreased(p<0.01),and in the remission group the levels were lower than normal(p<0.01). The levels of CXCL10、CCL22 were positively correlated with FT4( r=0.538，r=0.389, respectively). Conclusion: Th1/Th2 chemokines CXCL10、CCL22 were involved in the immune regulation of Graves

Key words: Graves disease, chemokine, autoimmune, CXCL10, CCL22