Abstract: [Abstract] Objective To observe the clinical effect of durg combination use in oral cavity on prevention of prophase oral infection and deep fungal infenction after liver transplantion. Methods To choose 162 liver transplantation patients were randomly divided into observation groupA(n=57), observation group B(n=62)and control group C(n=43)，For the experiment group , alternately use 3% sodium bicarbonate gargle and 0.1% cetylpyridinium chloride gargle to cavity nursing, And observation group B use 50000 U/ml nystatin aqueous suspension combine with 0.1% cetylpyridinium chloride gargle in turn to oral nursing, control group C only with normal saline nursing oral cavity ,then the oral complication in every groups was investigated,and make plasma (1-3)-β-D-glucan test. Results The oral complication and (1-3)-β-D-glucan test level were no difference between observation groupA and observation group B(P＞0.05);but showed significant differentces between observation groupA and observation group B to contrast control group C (P＜0.05). Conclusions There were important meaning in use 0.1% cetylpyridinium chloride gargle combine with 3% sodium bicarbonate gargle and 50000 U/ml nystatin aqueous suspension respectively to oral nursing, on prevention of prophase oral infection and deep fungal infenction after liver transplantion.

Key words: liver transplantation, oral complication, deep fungal infection, local application