Abstract: Abstract: During liver transplantation, the anhepatic phase can induce ischemic reperfusion (IR) injury of the liver and therefore cause dysfunction of remote organs, especially gut. The IR can lead to intestine congestive ischemia and gastrointestinal congestion, which leads to intestinal injury. The epithelial cells of the intestinal mucosa are sensitive to the hypoxia-ischemia upon intestinal congestion, and they are often subjected to apoptosis and necrosis after surgery. Necroptosis is mediated by death receptor ligation when apoptotic pathway is inhibited. The complexⅡ, which is formed by increasing aggregation of receptor-interacting serine/threonine protein kinase 1 (RIPK1)，and the interaction between RIPK1 and RIPK3 are the key elements for the activation of necroptosis signaling pathway. This article reviews the molecular mechanisms of necroptosis in IR of liver transplantation.

Key words: necroptosis, intestinal injury, receptor-interacting protein, liver transplantation