Abstract: Abtract Objective: To detect the concentration of PAPP-A in the serum of the normal individuals, SAP and ACS, and analyze its clinical value. Methods: Picked 117 ACS samples, and followed all of them after therapy three weeks later. Also, picked 68 samples of SAP and 84 of nomal controls. Then, all of the above were detected with the ELISA method. Results: the concentration of PAPP-A in the samples of the normal individuals, ACS and SAP, the concentration in the ACS was highest, which had significant statistical meanings, (q1=23.73, q2=31.32, P<0.01). However, the findings between SAP and normal ones had non-statistical meaning, (q3=0.54, P>0.05). Also, we found that the PAPP-A congcentration had significant statistical meanings, (t=12.831, P<0.01). Conclusion: PAPP-A was of great value in detecting the ACS samples, complexed with the symptoms and other markers, it can have a much better application in predicting and preventing the ACS, if the sensitivity becomes higher, the clinical application of PAPP-A can be better.

Key words: pregnancy-associated plasma protein A, acute coronary syndrome, atherosclerosis, ELISA, marker