Abstract: Abstract Objective: To prospectively study the clinical efficacy of combined administration of pseudomonas aeruginosa-mannose sensitive hemagglutinin (PA-MSHA) and talcum powder in the treatment of malignant pleural effusion. Methods: 72 patients suffered from malignant pleural effusion were randomly divided into one observation group (28 cases) and two control groups (24 cases and 20 cases respectively). Patients in the observation group were given combined use of PA-MSHA and talcum powder, while patients in two control groups received PA-MSHA and talcum powder respectively. All the patients received thoracic close drainage by central vein catheterization set. Then the medicine was injected into thoracic cavity through the catheter. The weekly administration lasted 1~3 weeks depending on clinical efficacy. Results: The total effective rate of treatment group was higher than control groups (P<0.05). Compared with control groups, the treatment group showed no significant difference in serious side effects. Conclusion: Combined administration of PA-MSHA and talcum powder through thoracic drainage catheter proved to be a safe and effective method.

Key words: Malignant pleural effusion, Treatment, Pleurodesis, Talcum powder, PA-MSHA