Abstract: [ABSTRACT] Objective: To study the possibility of ANXA5 as a differentiation type marker of uterine cervical carcinoma by examining expression of ANXA5 in the three kinds of pathology differentiation. Methods: All the specimens are classified as well-differentiated，intermediate-differentiated and poor-differentiated groups according to HE stainning. RT-PCR method was used to determine the ANXA5 mRNA expression; Western Blot method and immunohistochemistry were employed to determine the ANXA5 protein expression. The results between any two groups were analysed by t test. Results: ANXA5 expression in poor-differentiated and intermediate-differentiated groups increased drastically while the expression in well-differentiated group only lightly increased, which has significant difference with the other two groups（P<0.05）. Conclusion: ANXA5 maybe a potential marker for the differentiation types of uterine cervical carcinoma.

Key words: annexin A5, cell differentiation, uterine cervical carcinoma, expression