Abstract: 【Abstract】 Objective TO study the therapeutic effects of inhaled intric oxide(iNO) and high-frequencey oscillatory ventilation in neonatal perisistent pulmonary hypertension (PPHN).Methods 30 neonates with pulmonary angiospasm and 6 patients with anatomic vascular obstruction were thrapied.During high-frequencey oscillatory ventilation,NO was added into ventilator circle. Oxygenation indes(OI),blood gas analysis,blood pressure,pulmonary arterial systolic pressure(SPAP), heart rate,mean airway pressure(MAP)，saturation of blood oxygen per cutem(TcSaO2),methaemoglobin (MetHb),and nitrogen dioxide (NO2)30 minutes and 24 hours after NO therapy were monitored. Results In group Ⅰtwenty-six (86.67%)neonates survived,the oxygenation were improved.There were no significant adverse reaction.In group Ⅱ,there were no remarkable changes. Conclusion Inhaling minimum effective dosage NO in PPHN with pulmonary angiospam was beneficial as soon as possible. Premature infants(≥34W)who was treated with high-frequencey oscillatory ventilation and NO were effective.

Key words: nitric oxide, high-frequencey oscillatory ventilation, neonatal persistent pulmonary hypertension