Abstract:

[Abstract] Objective   To investigate the expressions of PTEN and p21genes in Hazak patients with esophageal can
cer. Methods  The expressions of PTEN and p21genes were detected by RT-PCR in48samples (cancer tissues and normal tissues) of patients with esophageal cancer. The relationship between the expressions of PTEN and p21genes, tumor differentiation, TNM stage, clinical phase and lymph node metastasis were analyzed.  Results  The positive rates of PTEN genewere75% and45.8% in cancer and distant normal tissues. The expression of PTEN was significantly higher in cancer tissues than that of distant normal tissues (χ2=8.537，P＜0.05). The positive rates of p21gene were95.8% and97.9% in cancerand distant normal tissues, and no significant difference between them (χ2=0.344，P＞0.05).There was no correlation between expressions of PTEN and p21and the tumor differentiation, the depth of invasion and lymph node metastasis in esophageal cancer.Conclusion   PTEN and p21genes are not the primary genes for the carcinogenesis of esophageal cancer inHazak.

Key words: carcinoma, squamous cell, Esophageal neoplasms, RT-PCR, gene, tumor suppressor, proto- oncogene proteins p21(ras), 基因表达