Abstract: Object: Explore the incidence of diabetes in patients fatty liver disease at followed-up 5 years. Method: he crowd was used as the research objects who their first medical examination were performed during 2005.1-2006.12.in our hospital, the examining again before 2011.12.and having complete data, eliminating individuals with HBSAg (+), blood glucose abnormalities and massive alcohol intake. Some index were measured in all participants including height, weight, blood pressure, BMI, fasting blood sugar and blood fat, liver function and insulin levels, electrocardiogram and liver ultrasonography inspection. The objects were divide into the fatty liver disease group and the non fatty liver disease group according to liver ultrasonography inspection results at baseline levels, the insulin concentrations were divided into three levels:< 10ulu/ml, 10-15ulu/ml and >15ulu/ml. Comparison the change of the above indexes and incidence of diabetes between the two groups at follow-up 5 years. Result: (1) The incidence of fatty liver disease was 27.16% by color dopplar ultrasound diagnosis in our data at Baseline level. (2) There were statistically significant differences on age, gender, BMI, blood pressure, blood fat and blood sugar, ALT and AST between the two groups; the fasting insulin concentrations of the majority individuals were >15ulu/ml in fatty liver disease group , it were <10ulu/ml in non fatty liver disease group at Baseline level. (3) The total incidence of diabetes was 10.53% at 5 years of follow-up, having higher incidence of diabetes compared with general population, it was higher in the fatty liver disease group (16.7% vs 8.2%) with statistically significant. (4)Further analysis shows that there were the highest incidence of diabetes in fatty liver disease group with insulin >15ulu/ml level and it was the lower in non fatty liver disease group with insulin levels<10ulu/ml. At the same insulin levels, the incidence of diabetes was higher in fatty liver disease group. with insulin levels rise, the diabetes rate increases, the related analysis shows the difference having statistically significant. Conclusion: The fatty liver disease may involve in the course of adjusting the risk of developing diabetes in individual with insulin resistance.

Key words: fatty liver disease, diabetes, incidence, 5 years follow-up