Abstract:

[Abstract] Objective  To investigate the effects of lipoxin (LX) on the plasma nitric oxide (NO) concentration in preeclampsia rats, and make an experiment foundation for the treatment of human preeclampsia. Methods Thirty pregnant rats were randomly divided into three groups: normal group (saline), preeclampsia group (endotoxin) and LX group (endotoxin + LX). The experimental rat model of preeclampsia was established with small dose of endotoxin. LX was tail injected intravenously in the day that endotoxin was injected in LX group. The same volume of normal saline was tail injected intravenously in saline and endotoxin groups. Levels of blood pressure, urine protein and LX were detected on 8, 15 and 18 days after successful Modeling. The body weights of newborn rats were measured after operation on the 20th day of pregnancy. The NO concentration of abdominal aorta in mother rats was detected by nitrate reductase enzyme method. The level of LX was detected by double antibody sandwich method. Results  The endogenous lipoxin level was increased with the gestational age. The level of LX on 8 days of pregnancy was decreased in endotoxin group than that of saline group. The body weights of newborn rats and NO levels of pregnant rats were significantly higher in LX group than those of endotoxin group. There were significantly lower levels of blood pressure and urine protein in LX group than those of endotoxin group (P < 0.05). Conclusion  Lipoxin may be potentially useful in treatment of preeclampsia in rats．

Key words: Lipoxin A4, Experimental preeclampsia, Nitrogen monoxide, Rat