Abstract: Abstract  Objective  To study the incidence rate of dysbacteria after antibiotics applied in hemodialysis patients,expectation to approach the possible correlation between clinic index and dysbacteria. Methods  Those who have taken three more months hemodialysis were the HD group ,all of them needed antibiotic therapy. While the people who need antibiotic therapy but not accompanied by renal or digestive disease were allocate to control group. Recording their clinic index immediately after hospitalization , and the incidence rate of dysbacteria after antibiotics applied.Results   The incidence rate of dysbacteria was 34.5% in HD group while it was 18.1% in the control group; Among these clinic index age,creatinine and SGA is the factor that could impact dysbacteria, regression coefficients were 0.037（p<0.05）,0.003(p<0.05） and -1.152（p<0.001）respectively and OR was 1.307,1.003 and 0.316 . Conclusion   It is true that micro-ecological has been changed in hemodialysis, the incidence of dysbacteria is more often than the control group after antibiotics applied , age,creatinine and SGA is the factor that could impact dysbacteria,SGA is the protect factor.

Key words: Renal dialysis, Intestinal, diarrhea, bacterial infections, Ntibacterial agent