Abstract:

[Abstract] Objective To compare ratio of circulating Th17over Tc17cells in patients with colorectal polyp (CRP), colorectal adenoma (CRA) and colorectal cancer (CRC)，and analyse their relationship.Methods The ratio of circulating Th17over Tc17cells in93patients（17CRP,34CRA and42CRC）and17healthy donors were examined by flow cytometry; Serum levels of IL-17A and IL-23were tested by ELISA.Results The ratio of circulating Th17over Tc17cells and the se? rum levels of IL-17A and IL-23were the lowest in healthy control groups, medium in CRP and CRA groups and the highest in CRC groups (P<0.05). The proportions of Tc17cells in CRA groups were significantly higher compared to those in CRP groups，but no statistical significance of proportion of circulating Th17cells as well as serum levels of IL-17A and IL-23be? tween CRA and CRP groups was observed (P>0.05). Further analysis showed that there was a positive correlation between proportions of circulating Th17and Tc17cells (rs=0.594, P<0.001). Conclusion The proportions of circulating Th17and Tc17cells were positively related and the ratio of Th17over Tc17was markedly increased from CRP group or CRA group to CRC group.

Key words: Colorectal polyp, Colorectal adenoma, Colorectal cancer, Th17 cells, Tc17 cells, Cytokines