Abstract:

[Abstract] Objective   To investigate the clinical pathological features and prognosis of gastric carcinoma with neu?
roendocrine differentiation (NED) and mixed gonadal neuroendocrine carcinoma of the stomach (MANECs). Methods   A retrospective analysis of61cases of gastric carcinoma with NED and34cases of MANECs and their histochemistry and im?munohistochemistry were also observed. Prognosis of the2groups were compared by the Kaplan-Meiers survival analysis. Prognostic factors associated with patients with gastric cancer were analyzed by COX proportional hazards model.Results   Tumor location, distant metastasis and lymph node metastasis were statistically different between these2groups (P<0.05). Syn positive expression rate is higher than CgA and CD56in the gastric carcinoma with NED group; Postoperative survive pe?riod of the gastric carcinoma with NED is shorter than that of MANECs (P<0.05). Lymph node metastasis and distant region?al transfer is obviously correlated with prognosis (P<0.05). Conclusion   Immunohistochemistry is important for the diag?nosis of these two tumor. The number of neuroendocrine cells can help to assess prognosis and guide treatment.

Key words: stomach neoplasms, carcinoma, neuroendocrine, immunohistochemistry, prognosis, neuroendocrine differentiation, mixed gonadal neuroendocrine carcinoma of the stomach