Abstract: Abstract: Incidence of thrombotic disease is very high, and this disease can result in high mortality and high disability rate. Prevention and treatment of the disease mainly include: antiplatelet, anticoagulation and thrombolysis. Choice of anti⁃ thrombotic treatment based emphasizes on individuation. As a direct inhibitor of factor Xa, Rivaroxaban exert its anticoagu⁃ lant activity without antithrombin Ⅲ but is ineffective to the Ⅹa in prothrombin complex, which can be used as a substitute of traditional anticoagulant. In this paper, applications of Rivaroxaban on treating symptomatic venous thromboembolic dis⁃ ease, postoperative venous thrombosis and cardiovascular thrombosis are reviewed.

Key words: anticoagulants, factor Ⅹa, thrombosis, review, Rivaroxaban