Tianjin Med J ›› 2016, Vol. 44 ›› Issue (9): 1181-1184.doi: 10.11958/20160019

• Review • Previous Articles    

Current update on combined hepatocellular and cholangiocarcinoma

LIU Dongming, CHEN Lu, TIAN Yao, ZHANG Xihao, LI Qiang△   

  1. Tianjin Medical University Cancer Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China
  • Received:2016-01-15 Revised:2016-05-22 Published:2016-09-15 Online:2016-09-28
  • Contact: LI Qiang E-mail:liqiang4016@yahoo.com

Abstract: Combined hepatocellular and cholangiocarcinoma (HCC-CC) is a rare primary hepatic neoplasm (PHN) with features of both hepatocellular and biliary differentiation. Hepatitis B and hepatitis C are the major causes of HCC-CC. Surgical treatment is the main therapeutic method for HCC-CC. For patients with unresectable lesions, curative or palliative locoregional therapy is applied, including radiofrequency ablation (RFA), transarterial chemoembolization (TACE) and supportive treatment. Because of the rare occurrence and ambiguous clinical features of HCC- CC, it is most often misdiagnosed with the other two types of primary liver cancer. Thus, the realization of the current progress of combined hepatocellular and cholangiocarcinoma is particularly important for us. This article aims to summarize the epidemiology and clinical futures, the treatment and prognosis, the progress of genetics and molecular analysis of HCC-CC.

Key words: carcinoma, hepatocellular, bile duct neoplasms, review, combined hepatocellular and cholangiocarcinoma