Abstract: Abstract: Objective　To explore the diagnostic value of improved Cornell voltage in hypertensive patients with left ventricular hypertrophy (LVH). Methods　Data of 381 patients (male 233, female 148) with hypertension were retrospectively analyzed. The different ECG indicators were collected and calculated including improved Cornell voltage (sum of the maximum S-wave or QS amplitudes in 12 leads and R amplitudes of aVL lead), SD (maximum S-wave or QS amplitude in 12 leads), Cornell voltage (sum of the amplitude of S wave of V3 lead and R wave of aVL lead) and Sokolow-Lyon voltage (sum of the amplitude of the S wave of V1 and the amplitude of R wave of V5 or V6). The left ventricular mass index (LVMI) measured by echocardiography was used as the gold standard for diagnosis of LVH. Patients were divided into no-LVH group (n=213, male 143, female 70) and LVH group (n=168, male 90, female 78). The improved Cornell voltage, SD, Cornell voltage and Sokolow-Lyon voltage were compared between the two groups. The diagnostic value of various indexes for LVH was also compared between the two groups. Results Compared with the no-LVH group, the improved Cornell voltage, SD, Cornell voltage and Sokolow-Lyon voltage were significantly higher in the LVH group (P＜0.01). In male patients with hypertension, the AUC, cut-off value, sensitivity, and specificity of improved Cornell voltage for the diagnosis of hypertension with LVH were 0.810, 1.60 mV, 86.67% and 67.83%, respectively. The diagnostic efficacy of improved Cornell voltage was better than that of SD, Cornell voltage and Sokolow-Lyon voltage (Z=2.501, 2.616 and 2.650, P＜0.05). In female patients with hypertension, the AUC, cut-off value, sensitivity and specificity of improved Cornell voltage for diagnosis of hypertension with LVH were 0.737, 1.45 mV, 70.51% and 68.57%, respectively. The diagnostic efficacy of improved Cornell voltage was better than that of Cornell voltage and Sokolow-Lyon voltage (Z=2.632 and 2.404, P＜0.05). Stepwise Logistic regression analysis of binary classification found that improved Cornell voltage and diastolic blood pressure were independent risk factors of LVH(P＜0.01). Conclusion　The diagnostic value of improved Cornell voltage is better than Cornell voltage and Sokolow-Lyon voltage in hypertensive patients with left ventricular hypertrophy.

Key words: hypertension, hypertrophy,left ventricular, electrocardiography, echocardiography, left ventricular hypertrophy, improved Cornell voltage