Research progress on the role of cartilage oligomeric matrix protein in human diseases

doi:10.11958/20202516

Tianjin Medical Journal ›› 2021, Vol. 49 ›› Issue (3): 330-336.doi: 10.11958/20202516

Research progress on the role of cartilage oligomeric matrix protein in human diseases

JIN Lian-chi1, LAI Yong-jie2△

1 Zhuhai Campus of Zunyi Medical University/Education and Innovation Base for Immunology Graduate Students in Guizhou Province, Zhuhai 519041, China; 2 Department of Immunology and Pathogenic Biology, Zhuhai Campus of Zunyi Medical University

Received:2020-09-11 Revised:2020-11-29 Published:2021-03-15 Online:2021-03-15

JINLian-chi, LAIYong-jie△. Research progress on the role of cartilage oligomeric matrix protein in human diseases[J]. Tianjin Medical Journal, 2021, 49(3): 330-336.

Abstract

Abstract: Cartilage oligomeric matrix protein (COMP) is a non-collagenous glycoprotein component of extracellular matrix (ECMs). COMP interacts with other ECMs, cell adhesive proteins, growth factors via its multi-functional domains. COMP is known to play a role in the development of miscellaneous human diseases. This paper reviews the basic structure and function of COMP and its role in the pathogenesis of joint and cardiovascular diseases, tissue fibrosis and cancer.

Key words: cartilage oligomeric matrix protein, extracellular matrix, biomarkers, fibrosis

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Research progress on the role of cartilage oligomeric matrix protein in human diseases

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