Abstract: Abstract: Caveolae and its related proteins are closely related to the occurrence and development of breast cancer. Caveolins include Cav-1, Cav-2 and Cav-3, among which Cav-1 is the most concerned. According to different molecular types and stages of breast cancer, Cav-1 play a dual role as tumor suppressor and tumor promoter and affect cell proliferation, apoptosis, migration, invasion and metastasis of tumor. Cav-2 can also inhibit and promote cancer. Cav-2 can not only cooperate with Cav-1, but also play a regulatory role independently. At present, Cav-3 is less studied in breast cancer. Alblation of Cav-3 can form an anti-tumor microenvironment. Cavins include Cavin-1, Cavin-2, Cavin-3 and Cavin-4. Cavin-1 can inhibit membrane tubule formation induced by Cav-1, and its specific role in breast cancer remains controversial. As a breast cancer suppressor, Cavin-2 can inhibit the progression of breast cancer by blocking TGF - β signaling pathway. Cavin-3 plays an anti-tumor role in breast cancer, but its specific mechanism is still unclear. The relationship between Cavin-4 and breast cancer is still not clear.

Key words: breast neoplasms, membrane proteins, Caveolins, neoplasm metastasis, Cavins