Abstract: Abstract: Objective　To investigate the effects of preoperative nasal drip and intraoperative intravenous infusion of dexmedetomidine on negative postoperative behavioral changes (NPOBCs) in children under general anesthesia. Methods　A total of 237 children who underwent laparoscopic surgery were randomly divided into three groups: the group P (received intranasal dexmedetomidine 2 μg/kg at the 30 minutes before operation, and intravenous infusion of saline 0.5 mL/kg for 10 min after intubation), the group I (received intranasal 0.02 mL/kg normal saline 30 min before operation, and intravenous infusion of dexmedetomidine 0.5 μg/kg for 10 min after intubation), the group C (received intranasal 0.02 mL/kg normal saline 30 min before operation, and intravenous infusion of saline 0.5 mL/kg for 10 min after intubation). Modified Yale Pre-operative Anxiety Scale, ICC scores, extubation time, recovery time, PACU time, FLACC scores, agitation and perioperative adverse events were recorded. The parents were followed up by telephone at 1, 7 and 30 days after operation using PHBQ. The behavior changes after operation were observed in children. Results　Compared with the group C and the group I, the ICC scores decreased in the group P (P＜0.05). Compared with the group C and the group P, the extubation time, recovery time and PACU time were prolonged in the group I (P＜0.05). Compared with the group C, the FLACC scores and the incidence of agitation were significantly lower in the group P and the group I (P＜0.05). Compared with the group C, the incidence of NPOBCs decreased on the 1st and 7th day after operation in the group P and the group I (P＜0.05), and the incidence of separation anxiety decreased on the 1st and 7th day after operation in the group P and the group I (P＜0.05). Conclusion　The intranasal and intraoperative intravenous infusion dexmedetomidine in children undergoing laparoscopic surgery can improve NPOBCs on the 1st and 7th day after operation, mainly to reduce separation anxiety. There is no significant difference in the prevention intensity of NPBOCs between the two administration methods.

Key words: dexmedetomidine, infusions, intravenous, administration, intranasal, laparoscopic surgery, postoperative behavioral changes, child