The utilization of ropivacaine combined with hydromorphone in caudal block for children undergoing hypospadias surgery

doi:10.11958/20221210

Abstract

CLC Number:

R614

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References 16

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[2]	BENKA A U, PANDUROV M, GALAMBOS I F, et al. Effects of caudal block in pediatric surgical patients:A randomized clinical trial[J]. Braz J Anesthesiol, 2020, 70(2):97-103. doi:10.1016/j.bjan.2019.12.003.
[3]	EKSTEIN M, WEINBROUM A A, BEN-CHAIM J, et al. Comparison of caudal block vs. penile block vs. intravenous fentanyl only in children undergoing penile surgery:A prospective,randomized,double blind study[J]. Front Pediatr, 2021, 9:654015. doi:10.3389/fped.2021.654015.
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[5]	CRAMER J. Comparison of morphine- and hydromorphone-containing patient-controlled epidural analgesia solutions in pediatric postoperative patients[J]. J Pediatr Pharmacol Ther, 2019, 24(1):22-26. doi:10.5863/1551-6776-24.1.22.
[6]	THIGPEN J C, ODLE B L, HARIRFOROOSH S. Opioids:A review of pharmacokinetics and pharmacodynamics in neonates,infants,and children[J]. Eur J Drug Metab Pharmacokinet, 2019, 44(5):591-609. doi:10.1007/s13318-019-00552-0.
[7]	SHARPE E E, MOLITOR R J, ARENDT K W, et al. Intrathecal morphine versus intrathecal hydromorphone for analgesia after cesarean delivery:A randomized clinical trial[J]. Anesthesiology, 2020, 132(6):1382-1391. doi:10.1097/ALN.0000000000003283.
[8]	KRANE E J, JACOBSON L E, LYNN A M, et al. Caudal morphine for postoperative analgesia in children:A comparison with caudal bupivacaine and intravenous morphine[J]. Anesth Analg, 1987, 66(7):647-653.
[9]	KUNDU R, BAIDYA D K, ARORA M K, et al. Caudal bupivacaine and morphine provides effective postoperative analgesia but does not prevent hemodynamic response to pneumoperitoneum for major laparoscopic surgeries in children[J]. J Anesth, 2015, 29(4):618-621. doi:10.1007/s00540-015-1983-2.
[10]	SATO M. Ultrasound-guided quadratus lumborum block compared to caudal ropivacaine/morphine in children undergoing surgery for vesicoureteric reflex[J]. Paediatr Anaesth, 2019, 29(7):738-743. doi:10.1111/pan.13650.
[11]	GUO J, ZHUANG P, LIU K, et al. Effects of an individualized analgesia protocol on the need for medical interventions after adenotonsillectomy in children:a randomized controlled trial[J]. BMC Anesthesiol, 2021, 21(1):41. doi:10.1186/s12871-021-01263-3.
[12]	LUNDBLAD M, LÖNNQVIST P A. Adjunct analgesic drugs to local anaesthetics for neuroaxial blocks in children[J]. Curr Opin Anaesthesiol, 2016, 29(5):626-631. doi:10.1097/ACO.0000000000000372.
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组别	年龄（岁）	身高（cm）	体质量（kg）
R组	1.95±0.73	88.96±7.27	12.63±2.17
HR组	1.84±0.76	88.85±9.28	12.69±2.41
t	0.765	0.069	1.018

组别	年龄（岁）	身高（cm）	体质量（kg）
R组	1.95±0.73	88.96±7.27	12.63±2.17
HR组	1.84±0.76	88.85±9.28	12.69±2.41
t	0.765	0.069	1.018

组别	1 h	6 h	12 h	18 h	24 h
R组	4.9±0.6	5.8±0.7	7.1±0.8	8.1±0.8	6.9±0.6
HR组	4.8±0.6	5.5±0.8	6.0±0.7	7.3±0.8	6.8±0.7
t	1.110	1.422	7.183^＊＊	5.920^＊＊	1.189

组别	1 h	6 h	12 h	18 h	24 h
R组	4.9±0.6	5.8±0.7	7.1±0.8	8.1±0.8	6.9±0.6
HR组	4.8±0.6	5.5±0.8	6.0±0.7	7.3±0.8	6.8±0.7
t	1.110	1.422	7.183^＊＊	5.920^＊＊	1.189

组别	手术时间（min）	麻醉时间（min）	苏醒时间（min）
R组	133.2±54.6	183.8±54.5	12（8，18）
HR组	129.7±64.5	178.9±72.8	10（10，12）
t或Z	0.305	0.400	1.812

The utilization of ropivacaine combined with hydromorphone in caudal block for children undergoing hypospadias surgery

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组别	恶心呕吐	低氧血症	呼吸抑制/暂停	瘙痒	支气管痉挛	喉痉挛	住院时间（d）
R组	4（7.3）	6（7.3）	2（3.6）	0	0	0	11.2±1.6
HR组	6（10.9）	7（9.1）	3（5.5）	2（3.6）	0	0	11.4±2.1
χ²、P或t	0.440	0.087	0.210	0.495^△	-	-	0.664

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