Expression levels of plasma SIRT-1 and syndecan-1 in patients with sepsis-induced ALI/ARDS and their effect on prognosis

doi:10.11958/20221108

Abstract

CLC Number:

R563.8

Figures/Tables 5

References 21

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组别	n	SIRT-1	syndecan-1
对照组	50	1.42±0.36	211.24±57.26
ALI/ARDS组	106	0.81±0.27	501.67±81.32
t		11.790^＊＊	22.719^＊＊

组别	n	SIRT-1	syndecan-1
对照组	50	1.42±0.36	211.24±57.26
ALI/ARDS组	106	0.81±0.27	501.67±81.32
t		11.790^＊＊	22.719^＊＊

组别	n	男性	年龄（岁）	BMI （kg/m²）	原发疾病				APACHEⅡ （分）	LIS （分）	SIRT-1 （μg/L）	syndecan-1 （μg/L）
组别	n	男性	年龄（岁）	BMI （kg/m²）	呼吸道感染	尿路感染	腹腔感染	其他	APACHEⅡ （分）	LIS （分）	SIRT-1 （μg/L）	syndecan-1 （μg/L）
生存组	66	36（54.55）	56.71±9.42	22.25±2.31	30（45.45）	14（21.21）	12（18.18）	10（15.15）	19.89±6.42	1.98±0.22	0.96±0.27	451.19±72.35
死亡组	40	25（62.50）	58.04±9.89	22.01±2.08	22（55.00）	8（20.00）	7（17.50）	3（7.50）	28.43±9.33	2.28±0.25	0.56±0.22	584.97±90.31
t		0.645	0.691	0.538	1.676				5.570^＊＊	6.246^＊＊	7.909^＊＊	8.391^＊＊

组别	n	男性	年龄（岁）	BMI （kg/m²）	原发疾病				APACHEⅡ （分）	LIS （分）	SIRT-1 （μg/L）	syndecan-1 （μg/L）
组别	n	男性	年龄（岁）	BMI （kg/m²）	呼吸道感染	尿路感染	腹腔感染	其他	APACHEⅡ （分）	LIS （分）	SIRT-1 （μg/L）	syndecan-1 （μg/L）
生存组	66	36（54.55）	56.71±9.42	22.25±2.31	30（45.45）	14（21.21）	12（18.18）	10（15.15）	19.89±6.42	1.98±0.22	0.96±0.27	451.19±72.35
死亡组	40	25（62.50）	58.04±9.89	22.01±2.08	22（55.00）	8（20.00）	7（17.50）	3（7.50）	28.43±9.33	2.28±0.25	0.56±0.22	584.97±90.31
t		0.645	0.691	0.538	1.676				5.570^＊＊	6.246^＊＊	7.909^＊＊	8.391^＊＊

变量	β	SE	Wald χ²	P	OR（95%CI）
APACHEⅡ	0.542	0.245	4.894	0.027	1.719（1.064~2.779）
LIS	0.767	0.284	7.294	0.007	2.153（1.234~3.757）
SIRT-1	-0.271	0.118	5.274	0.022	0.763（0.605~0.961）
syndecan-1	0.891	0.321	7.705	0.006	2.438（1.299~4.573）
常数项	0.357	0.174	4.210	0.040	1.429

Expression levels of plasma SIRT-1 and syndecan-1 in patients with sepsis-induced ALI/ARDS and their effect on prognosis

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指标	AUC及95%CI	截断值	敏感度（%）	特异度（%）	约登指数
APACHEⅡ	0.756（0.661~0.851）	24分	75.00	71.21	0.462
LIS	0.762（0.668~0.855）	2分	57.50	86.36	0.439
SIRT-1	0.860（0.791~0.930）	0.77 μg/L	77.50	84.85	0.624
syndecan-1	0.870（0.800~0.940）	495.75 μg/L	82.50	81.82	0.643

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