Tianjin Medical Journal ›› 2023, Vol. 51 ›› Issue (4): 376-381.doi: 10.11958/20221083
• Experimental Research • Previous Articles Next Articles
JIANG Xiaocui(), TIAN Daizhi, ZHAO Min, GONG Jian, YU He, JIANG Xingyu, XIAO Min(
)
Received:
2022-07-08
Revised:
2022-11-10
Published:
2023-04-15
Online:
2023-04-20
Contact:
XIAO Min
E-mail:280185855@qq.com;531637551@qq.com
JIANG Xiaocui, TIAN Daizhi, ZHAO Min, GONG Jian, YU He, JIANG Xingyu, XIAO Min. Effects and mechanism of hyperuricemia on spermatogenesis and sperm quality in mice[J]. Tianjin Medical Journal, 2023, 51(4): 376-381.
CLC Number:
组别 | UA(μmol/L) | BUN(mmol/L) | Cre(μmol/L) |
---|---|---|---|
对照1 d组 | 38.65±9.36 | 3.30±0.75 | 43.95±3.73 |
氧嗪酸钾1 d组 | 147.86±37.33 | 4.00±0.73 | 47.45±4.63 |
t | 7.009** | 1.634 | 1.444 |
对照7 d组 | 36.51±7.09 | 3.67±0.26 | 45.02±5.52 |
氧嗪酸钾7 d组 | 178.95±37.21 | 5.94±1.01 | 50.26±4.21 |
t | 9.210** | 5.342** | 1.848 |
对照14 d组 | 39.15±7.94 | 4.46±0.65 | 45.40±2.37 |
氧嗪酸钾14 d组 | 190.97±53.07 | 6.90±1.03 | 48.75±3.63 |
t | 6.930** | 6.947** | 1.887 |
Tab.1 The serum levels of UA, BUN and Cre in six groups of mice
组别 | UA(μmol/L) | BUN(mmol/L) | Cre(μmol/L) |
---|---|---|---|
对照1 d组 | 38.65±9.36 | 3.30±0.75 | 43.95±3.73 |
氧嗪酸钾1 d组 | 147.86±37.33 | 4.00±0.73 | 47.45±4.63 |
t | 7.009** | 1.634 | 1.444 |
对照7 d组 | 36.51±7.09 | 3.67±0.26 | 45.02±5.52 |
氧嗪酸钾7 d组 | 178.95±37.21 | 5.94±1.01 | 50.26±4.21 |
t | 9.210** | 5.342** | 1.848 |
对照14 d组 | 39.15±7.94 | 4.46±0.65 | 45.40±2.37 |
氧嗪酸钾14 d组 | 190.97±53.07 | 6.90±1.03 | 48.75±3.63 |
t | 6.930** | 6.947** | 1.887 |
组别 | AST | ALT | XO |
---|---|---|---|
对照1 d组 | 109.33±18.25 | 20.83±2.54 | 30.76±2.61 |
氧嗪酸钾1 d组 | 123.78±16.26 | 21.01±1.87 | 32.71±2.08 |
t | 1.448 | 0.140 | 1.432 |
对照7 d组 | 107.25±14.51 | 19.17±1.89 | 30.52±2.92 |
氧嗪酸钾7 d组 | 150.41±20.54 | 20.82±3.33 | 40.02±4.67 |
t | 4.203** | 1.055 | 4.225** |
对照14 d组 | 107.59±16.76 | 20.47±2.05 | 32.50±1.63 |
氧嗪酸钾14 d组 | 165.93±19.57 | 22.98±3.24 | 37.26±5.00 |
t | 5.546** | 1.602 | 2.215 |
Tab.2 The serum levels of AST, ALT and XO in six groups of mice
组别 | AST | ALT | XO |
---|---|---|---|
对照1 d组 | 109.33±18.25 | 20.83±2.54 | 30.76±2.61 |
氧嗪酸钾1 d组 | 123.78±16.26 | 21.01±1.87 | 32.71±2.08 |
t | 1.448 | 0.140 | 1.432 |
对照7 d组 | 107.25±14.51 | 19.17±1.89 | 30.52±2.92 |
氧嗪酸钾7 d组 | 150.41±20.54 | 20.82±3.33 | 40.02±4.67 |
t | 4.203** | 1.055 | 4.225** |
对照14 d组 | 107.59±16.76 | 20.47±2.05 | 32.50±1.63 |
氧嗪酸钾14 d组 | 165.93±19.57 | 22.98±3.24 | 37.26±5.00 |
t | 5.546** | 1.602 | 2.215 |
组别 | D(μm) | M(μm) | P(分) | S(分) | TMS(分) |
---|---|---|---|---|---|
对照组 | 86.04±8.21 | 3.14±0.50 | 4.46±0.40 | 4.88±0.20 | 17.33±0.67 |
模型组 | 66.52±6.10 | 3.92±0.35 | 3.65±0.24 | 3.96±0.19 | 12.30±0.84 |
t | 4.269** | 2.855* | 3.883** | 7.389** | 10.433** |
Tab.3 Changes of testicular spermatogenic function in the two groups
组别 | D(μm) | M(μm) | P(分) | S(分) | TMS(分) |
---|---|---|---|---|---|
对照组 | 86.04±8.21 | 3.14±0.50 | 4.46±0.40 | 4.88±0.20 | 17.33±0.67 |
模型组 | 66.52±6.10 | 3.92±0.35 | 3.65±0.24 | 3.96±0.19 | 12.30±0.84 |
t | 4.269** | 2.855* | 3.883** | 7.389** | 10.433** |
组别 | 精子密度(×106/mL) | 精子活动率(%) |
---|---|---|
对照组 | 52.83±6.61 | 56.83±7.50 |
模型组 | 32.50±9.73 | 44.01±5.48 |
t | 4.235** | 3.378** |
Tab.4 Changes of sperm density and motility in the two groups
组别 | 精子密度(×106/mL) | 精子活动率(%) |
---|---|---|
对照组 | 52.83±6.61 | 56.83±7.50 |
模型组 | 32.50±9.73 | 44.01±5.48 |
t | 4.235** | 3.378** |
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