Research progress of amyotrophic lateral sclerosis related immune cells

doi:10.11958/20230187

Abstract

Abstract:

Abstract: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease, and its pathogenesis includes glutamate excitotoxicity, oxidative stress injury, abnormal aggregation of neurofilaments, abnormal aggregation of intracellular calcium, neurotrophic factor deficiency, mitochondrial dysfunction, RNA metabolism disorder and immune dysfunction. This article reviews the effects of monocytes/macrophages, natural killer cells, astrocytes, microglia, CD4⁺T cells, CD8⁺ T cells and the number and function of regulatory T cells on ALS.

Key words: amyotrophic lateral sclerosis, immune cell, immune response

CLC Number:

R746.4

References 34

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