Efficacy of capsaicin combined with repetitive transcranial magnetic stimulation in patients with dysphagia after stroke

doi:10.11958/20231579

Abstract

Abstract:

Objective To investigate the efficacy of capsaicin combined with repetitive transcranial magnetic stimulation (rTMS) in the treatment of dysphagia after stroke. Methods A total of 85 stroke patients with dysphagia and no true bulbar palsy were included and divided into 3 groups by random number table method: the capsaicin group (28 cases), the rTMS group (29 cases) and the capsaicin combined with rTMS group (28 cases). On the basis of conventional rehabilitation treatment, patients of the capsaicin group were given capsaicin to stimulate oropharynx 3 times a day (30 min before breakfast, lunch and dinner) for 6 days/week. Patients of the rTMS group were given S1 hot spot magnetic stimulation of the primary somatosensory cortex on the healthy side, once a day, 6 times a week, and patients of the capsaicin combined with rTMS group were treated with capsaicin combined with S1 hot spot magnetic stimulation. The treatment course of the 3 groups was 3 weeks. Before and after treatment, patients were evaluated by WST, SSA, EAT-10 and VFSS, respectively, to determine the degree of improvement in their swallowing function. Results There were no significant differences in WST, SSA, EAT-10 and VFSS scores before treatment between the 3 groups, and the above indexes were improved after treatment in the 3 groups. The improvement in the capsaicin combined with rTMS group was more obvious than that of the other 2 groups (P<0.05). Conclusion Capsaicin combined with rTMS can significantly improve swallowing function of patients with swallowing disorder after stroke compared with capsaicin or rTMS alone.

Key words: stroke, capsaicin, transcranial magnetic stimulation, deglutition disorders, oropharynx

CLC Number:

R743.3

Figures/Tables 6

References 21

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组别	n	性别（男/女）	年龄/岁	病程/d	MMSE 评分/分
辣椒素组	28	21/7	56.11±10.67	47.07±15.17	21.00±4.31
rTMS组	29	20/9	57.97±10.49	41.79±13.91	21.10±4.56
联合组	28	18/10	58.18±9.77	45.96±14.99	22.29±3.48
χ²或F		0.761	0.311	1.028	0.833

组别	n	性别（男/女）	年龄/岁	病程/d	MMSE 评分/分
辣椒素组	28	21/7	56.11±10.67	47.07±15.17	21.00±4.31
rTMS组	29	20/9	57.97±10.49	41.79±13.91	21.10±4.56
联合组	28	18/10	58.18±9.77	45.96±14.99	22.29±3.48
χ²或F		0.761	0.311	1.028	0.833

组别	n		WST分级					Z
组别	n		1	2	3	4	5	Z
辣椒素组	28	治疗前	0	0	13	13	2	4.458^＊＊
辣椒素组	28	治疗后	3	10	12	3	0	4.458^＊＊
rTMS组	29	治疗前	0	0	12	15	2	4.548^＊＊
rTMS组	29	治疗后	2	12	11	4	0	4.548^＊＊
联合组	28	治疗前	0	0	13	14	1	5.434^＊＊
联合组	28	治疗后^ab	8	13	5	2	0	5.434^＊＊

组别	n		WST分级					Z
组别	n		1	2	3	4	5	Z
辣椒素组	28	治疗前	0	0	13	13	2	4.458^＊＊
辣椒素组	28	治疗后	3	10	12	3	0	4.458^＊＊
rTMS组	29	治疗前	0	0	12	15	2	4.548^＊＊
rTMS组	29	治疗后	2	12	11	4	0	4.548^＊＊
联合组	28	治疗前	0	0	13	14	1	5.434^＊＊
联合组	28	治疗后^ab	8	13	5	2	0	5.434^＊＊

组别	n	治疗前	治疗后	t
辣椒素组	28	30.61±3.72	25.61±4.32	4.647^＊＊
rTMS组	29	30.37±3.53	25.20±4.45	4.683^＊＊
联合组	28	29.56±3.34	22.67±3.03^ab	8.174^＊＊