Study on the correlation between serum SACE, MMP-9 and HPT with pulmonary infection in patients with schizophrenia

doi:10.11958/20241727

Abstract

Abstract:

Objective To explore the correlation between serum angiotensin-converting enzyme (SACE), matrix metalloproteinase-9 (MMP-9) and haptoglobin (HPT) with pulmonary infection in patients with schizophrenia. Methods A total of 83 patients with schizophrenia were selected and divided into the infected group (40 cases) and the non-infected group (43 cases) according to whether they had pulmonary infection. Data of antipsychotic drugs, length of hospital stay, course of disease and electroconvulsive therapy were collected. Serum SACE, MMP-9 and HPT levels were detected by enzyme-linked immunosorbent assay. Spearman correlation analysis was used to determine serum SACE, MMP-9 and HPT and pulmonary infection in patients with schizophrenia. Logistic regression was used to analyze risk factors for pulmonary infection in patients with schizophrenia, and receiver operating characteristic (ROC) curves were used to evaluate the predictive value of serum SACE, MMP-9 and HPT in patients with pulmonary infection. Results Before treatment, the types of antipsychotic drugs ≥2, the proportion of electroconvulsive therapy, serum SACE, MMP-9 and HPT levels were higher in the infected group than those in the non-infected group (P<0.05). After treatment, there were no significant differences in serum SACE, MMP-9 and HPT levels between the infected group and the non-infected group (P>0.05). Serum SACE, MMP-9 and HPT were positively correlated with pulmonary infection in patients with schizophrenia (P<0.05). More than 2 types of antipsychotic drugs, electroconvulsive therapy and elevated SACE, MMP-9 and HPT were risk factors for pulmonary infection in schizophrenia patients (P<0.05). The ROC curve analysis showed that the combined serum SACE, MMP-9 and HPT for pneumonia in schizophrenic patients were better than each of these indicators alone in predicting pulmonary infection in patients with schizophrenia. Conclusion Serum SACE, MMP-9 and HPT are related with pulmonary infection in patients with schizophrenia, and which can be used as potential indicators for predicting pulmonary infection in patients with schizophrenia.

Key words: peptidyl-dipeptidase A, matrix metalloproteinase 9, haptoglobins, schizophrenia, pulmonary infection

CLC Number:

R749.3

Figures/Tables 5

References 16

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组别		抗精神病药物种类≥2种					住院时间≥ 30 d			病程≥3年		电休克治疗
无感染组		5（11.63）					21（48.84）			24（55.81）		9（20.93）
感染组		18（45.00）					24（60.00）			25（62.50）		26（65.00）
χ²		11.521^＊					1.040			0.383		16.504^＊
组别	n			男性	年龄/岁			家族史			无家庭照料者
无感染组	43			28（65.12）	37.91±4.15			12（27.91）			7（16.28）
感染组	40			23（57.50）	38.43±4.52			14（35.00）			9（22.50）
t或χ²				0.507	0.544			0.485			0.515
组别			高中及以上文化程度			居住地							糖尿病
组别			高中及以上文化程度			农村			城镇				糖尿病
无感染组			25（58.14）			21（48.84）			22（51.16）				3（6.98）
感染组			19（47.50）			17（42.50）			23（57.50）				6（15.00）
χ²			0.942			0.335							0.675

组别		抗精神病药物种类≥2种					住院时间≥ 30 d			病程≥3年		电休克治疗
无感染组		5（11.63）					21（48.84）			24（55.81）		9（20.93）
感染组		18（45.00）					24（60.00）			25（62.50）		26（65.00）
χ²		11.521^＊					1.040			0.383		16.504^＊
组别	n			男性	年龄/岁			家族史			无家庭照料者
无感染组	43			28（65.12）	37.91±4.15			12（27.91）			7（16.28）
感染组	40			23（57.50）	38.43±4.52			14（35.00）			9（22.50）
t或χ²				0.507	0.544			0.485			0.515
组别			高中及以上文化程度			居住地							糖尿病
组别			高中及以上文化程度			农村			城镇				糖尿病
无感染组			25（58.14）			21（48.84）			22（51.16）				3（6.98）
感染组			19（47.50）			17（42.50）			23（57.50）				6（15.00）
χ²			0.942			0.335							0.675

组别		n	SACE/（U/mL）
组别		n	治疗前		治疗后	t
无感染组		43	36.42±4.83		35.74±4.37	0.685
感染组		40	42.84±5.61		36.91±3.85	5.121^＊
t			5.594^＊		1.299
组别	MMP-9/（mg/L）
组别	治疗前			治疗后			t
无感染组	119.35±12.19			116.72±11.43			1.032
感染组	138.26±15.73			115.64±10.86			7.484^＊
t	6.148^＊			0.440
组别	HPT/（g/L）
组别	治疗前			治疗后			t
无感染组	1.93±0.26			1.82±0.21			2.158^＊
感染组	2.42±0.39			1.85±0.24			7.872^＊
t	6.554^＊			0.404

组别		n	SACE/（U/mL）
组别		n	治疗前		治疗后	t
无感染组		43	36.42±4.83		35.74±4.37	0.685
感染组		40	42.84±5.61		36.91±3.85	5.121^＊
t			5.594^＊		1.299
组别	MMP-9/（mg/L）
组别	治疗前			治疗后			t
无感染组	119.35±12.19			116.72±11.43			1.032
感染组	138.26±15.73			115.64±10.86			7.484^＊
t	6.148^＊			0.440
组别	HPT/（g/L）
组别	治疗前			治疗后			t
无感染组	1.93±0.26			1.82±0.21			2.158^＊
感染组	2.42±0.39			1.85±0.24			7.872^＊
t	6.554^＊			0.404

变量	β	SE	Wald χ²	P	OR（95%CI）
抗精神病药物种类	2.930	1.292	5.144	0.023	18.719（1.489~235.341）
电休克治疗	2.243	1.038	4.673	0.031	9.423（1.233~72.016）
SACE	0.383	0.132	8.360	0.004	1.467（1.131~1.902）
MMP-9	0.104	0.035	8.873	0.003	1.109（1.036~1.187）
HPT	6.640	2.515	6.973	0.008	765.440（5.539~105 777.685）
常数项	-44.400	12.449	12.720	<0.001	0.000