Efficacy study of a self-formulated pancreatic-cleansing and lipid-lowering formula combined with abdominal acupoint plasters in the treatment of hyperlipidaemic acute pancreatitis

doi:10.11958/20253179

Abstract

Abstract:

Objective To investigate the clinical efficacy of a proprietary formula for clearing pancreas and lowering lipids combined with abdominal acupoint application in treating hyperlipidaemic acute pancreatitis (HLAP). Methods Seventy patients with HLAP admitted between May 2024 to August 2025 were selected as study subjects, and patients were randomly divided into the observation group (n=35) and the control group (n=35). The control group received conventional Western medical treatment, while the observation group received a proprietary formula for clearing pancreas and lowering lipids combined with acupoint plaster therapy on the basis of the control group. Both groups were treated for 10 days. The clinical efficacy and incidence of adverse reactions were compared between the two groups. The levels of amylase, blood lipids and inflammatory factors in patients of two groups were measured before treatment, 3 days after treatment and 10 days after treatment. The modified CT severity index (MCTSI) was used for evaluation. Results The clinical total effective rate was significantly higher in the observation group than that of the control group (P<0.05). The results of repeated measurement analysis showed that there were statistically significant differences in levels of serum amylase, urine amylase, triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), serum C-reactive protein (CRP), white blood cell (WBC) and MCTSI score in terms of inter group effects, time effects and interaction effects (P<0.05). After 3 days and 10 days of treatment, the scores of serum amylase, urine amylase, TG, TC, LDL-C, CRP, WBC and MCTSI were decreased in both groups, while HDL-C increased. Moreover, after 3 days and 10 days of treatment the scores of serum amylase, urine amylase, TG, TC, LDL-C, CRP, WBC and MCTSI were lower in the observation group than those of the control group (P<0.05), and HDL-C level was higher than that of the control group. There were no significant differences in adverse reactions between the two groups (P>0.05). Conclusion The combination of a proprietary formula for clearing pancreas and lowering lipids with abdominal acupoint plaster application in the treatment of hyperlipidaemic acute pancreatitis enhances therapeutic efficacy, reduces blood lipid levels, alleviates inflammatory states, regulates microcirculation, accelerates symptom improvement and demonstrates safety.

Key words: pancreatitis, hyperlipidemias, acupoint sticking therapy, proprietary formula for clearing the pancreas and lowering lipids, hyperlipidaemic acute pancreatitis

CLC Number:

R576.1

Figures/Tables 7

References 19

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组别	年龄/岁	性别（男/女）	体质量指数/（kg/m²）	发病至入院时间/h
对照组	43.57±5.11	18/17	24.55±1.26	10.40±3.80
观察组	42.22±5.01	20/15	24.24±1.58	11.48±4.31
t或χ²	1.109	0.230	0.921	1.119

组别	年龄/岁	性别（男/女）	体质量指数/（kg/m²）	发病至入院时间/h
对照组	43.57±5.11	18/17	24.55±1.26	10.40±3.80
观察组	42.22±5.01	20/15	24.24±1.58	11.48±4.31
t或χ²	1.109	0.230	0.921	1.119

组别	显效	有效	无效	总有效
对照组	15（42.86）	13（37.14）	7（20.00）	28（80.00）
观察组	19（54.28）	15（42.86）	1（2.85）	34（97.14）
χ²				5.081^＊＊

组别	显效	有效	无效	总有效
对照组	15（42.86）	13（37.14）	7（20.00）	28（80.00）
观察组	19（54.28）	15（42.86）	1（2.85）	34（97.14）
χ²				5.081^＊＊

组别		血清淀粉酶
组别		治疗前	治疗3 d		治疗10 d
对照组		652.31±58.40	424.40±42.09^a		146.28±34.14^ab
观察组		647.62±57.43	382.11±37.12^a		120.37±25.61^ab
t		0.338	4.457^＊＊		3.592^＊＊
F_组间/F_时间/F_交互		15.700^＊＊/2 417.363^＊＊/3.217^＊
组别	尿淀粉酶
组别	治疗前			治疗3 d		治疗10 d
对照组	2 864.66±156.36			1 238.54±78.27^a		398.42±42.15^ab
观察组	2 889.62±161.35			1 089.51±75.40^a		304.43±36.07^ab
t	0.658			8.113^＊＊		10.040^＊＊
F_组间/F_时间/F_交互	25.995^＊＊/10 871.029^＊＊/8.711^＊＊