Progress in study on placenta-specific microRNAs and the pathogenesis of preeclampsia

doi:10.11958/20180189

Tianjin Med J ›› 2018, Vol. 46 ›› Issue (8): 890-893.doi: 10.11958/20180189

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Progress in study on placenta-specific microRNAs and the pathogenesis of preeclampsia

LIU Jiao1,2 , LIU Guo-long2 , GUO Zheng-chen2 , ZHANG Yun-shan3

1Department of Gynecology and Obstetrics, Binhai Hospital, Tianjin Medical University General Hospital, Tianjin 300480, China; 2 Tianjin Medical University; 3 Tianjin Central Hospital of Gynecology Obstetrics

Received:2018-02-01 Revised:2018-04-28 Published:2018-08-15 Online:2018-08-23

LIU Jiao1,2,LIU Guo-long2,GUO Zheng-chen2,ZHANG Yun-shan3. Progress in study on placenta-specific microRNAs and the pathogenesis of preeclampsia[J]. Tianjin Med J, 2018, 46(8): 890-893.

Abstract

Abstract: Preeclampsia, one of the pregnancy specific diseases, is a leading cause of new onset hypertension and proteinuria after 20 weeks. The preeclampsia pathogenesis includes abnormal placentation and maternal inflammatory response. MicroRNAs are a kind of non-coding RNAs that induce post-transcriptional suppression of target gene expression. In biomedical research, microRNAs can be used as the potential biomarkers to assess the development and prognosis of diseases. Whether the abnormal expression of placental-derived microRNAs is closely related to the occurrence and development of preeclampsia is still controversial. This article reviews the relationship between placental microRNAs and pathogenesis of preeclampsia.

Key words: eclampsia, microRNAs, placenta, biological markers, preeclampsia

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Progress in study on placenta-specific microRNAs and the pathogenesis of preeclampsia

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