Abstract: Objective To investigate the related factors of stage Ⅰ pulmonary adenocarcinoma with lymphovascular invasion. Methods Clinical data of 229 patients with stage Ⅰ lung adenocarcinoma treated by surgical treatment and pathologically diagnosed as stage Ⅰ lung adenocarcinoma in Tianjin Chest Hospital from January 2016 to May 2018 were retrospectively analyzed. The patients were divided into two groups: lymphovascular invasion group and non-lymphovascular invasion group, and the influencing factors of lymphovascular invasion for lung adenocarcinoma in stage Ⅰ were analyzed. Results The univariate factor analysis showed that pulmonary adenocarcinoma in stage Ⅰ with lymphovascular invasion was related to diameter of tumor, lepidic pattern, acinar pattern, papillary pattern, micropapillary pattern, pleural invasion, preoperative neutrophil-lymphocyte ratio (NLR) and preoperative carcinoembryonic antigen (CEA, P＜0.05). Multivariate Logistic regression analysis showed that diameter of tumor ≥ 2.2 cm, micropapillary pattern ≥ 12.8% and pleural invasion were the risk factors for lymphovascular invasion. Conclusion Attention should be paid to the risk factors of lymphovascular invasion in clinic, such as tumor diameter, micropapillary pattern and visceral pleural invasion. And the patients with lymphovascular invasion should be treated as early as possible so as to prolong their survival time.

Key words: lung neoplasms, adenocarcinoma, risk factors, prognosis, lymphovascular invasion