Abstract: MicroRNAs are small non-coding RNA molecules that are mainly involved in physiological and pathological processes including cancer, viral infection, inflammation and autoimmune diseases. The nuclear factor κB (NF - κB) is a transcriptional factor with a wide range of gene regulatory functions that participate in different biological processes such as inflammation, cell proliferation, tumor development, learning and memory. Some studies have suggested that microRNA is closely related to the NF-κB pathway and plays an inhibitory or activation role in regulating the NF-κB pathway. This article reviews the microRNAs involved in NF-κB signal regulation in rheumatoid arthritis.

Key words: arthritis, rheumatoid, microRNAs, NF-kappa B, signal pathway, review