Abstract: Abstract：Objective To investigate the stone risk factors in patients with Randall’s plaques by analyzing the 24-h urinary metabolic analysis. Methods From October 2017 to October 2018, 30 patients with Randall’s plaques, 20 patients with no - Randall’s plaques and 30 healthy people were collected, and 24-h urine samples were analyzed. The stone components were analyzed by infrared spectroscopy. Results There were no significant differences in size, location, side and composition of the stones between Randall’s plaque group and no-Randall’s plaque. The content of citric acid decreased, while the contents of oxalic acid and phosphoric acid increased in Randall’s plaque group than those of control group (P＜0.05). In Randall plaque group, the content of citric acid in 24-h urine decreased, while the contents of oxalic acid, phosphoric acid, sodium and calcium increased (P＜0.05). Compared with no-Randall’s plaque group, the contents of citric acid in 24 h urine decreased, and the contents of oxalic acid, phosphoric acid, sodium and calcium increased in Randall plaque group (P＜0.05). Conclusion The high sodium, calcium, oxalic acid, phosphoric acid and low citric acid in 24-hour urine of patients with Randall’s plaques have important effects on the occurrence and development of urolithiasis. The intake of oxalic acid, sodium, calcium and phosphoric acid should be limited and citric acid should be supplemented in patients with Randall’s plaque urolithiasis.

Key words: Randall’s plaque, urinary stone, 24-h urine, risk factors