Abstract: Abstract: CD326 is a transmembrane protein, which is expressed in some normal epithelial cells and participates in the formation of human embryo and the differentiation of the adult cells. Also CD326 is expressed in the epithelial carcinoma cells and plays an important role in the formation and spread of tumors. Since its discovery, CD326 has attracted much attention in the expression, significance, mechanism, diagnosis and treatment in various common malignant tumors. This paper discussed the structure feature of CD326, the relationship between CD326 and the tumor microenvironment, the significance of CD326 expression in normal stem cells and tumor cells, and the clinic application, in order to further study the application value of tumor-related molecules.

Key words: CD326, malignant tumor, review