Abstract: Abstract: Astragaloside Ⅳ (AS - Ⅳ) is an active ingredient from a kind of traditional Chinese herbal medicine astragalus membranaceus, which has the functions of invigorating and promoting yang, fixing surface and relieving sweat, diffusing edema and detoxifying muscles. Chinese herbal medicine astragalus membranaceus has been widely used in the treatment of cardiovascular diseases in China, and AS - Ⅳ is one of its important active ingredients. The main pharmacological effects of AS-Ⅳinclude the enhancement of immunity, anti-inflammatory, anti-oxidation and anti-virus. Recent studies on AS-Ⅳdemonstrated that AS-Ⅳ can participate in cardioprotection by regulating intracellular calcium homeostasis, anti-oxidation interaction, improving myocardial energy metabolism, inhibiting apoptosis and anti-cytotoxicity. This article concludes the relevant researches in order to provide reference for clinical study.

Key words: astragalus membranaceus, myocytes, cardiac, calcium, reactive oxygen species, mitochondria,
astragaloside Ⅳ