Abstract: Abstract: Leptin is a hormone produced mainly by white adipose tissue, and is closely associated with hepatic stellate cell activation. After binding with its functional receptor, leptin can affect the activation of hepatic stellate cells through JAK2/STAT3, PI3K/Akt, MAPK and other signaling pathways and related molecules. The activation of hepatic stellate cells is a key link in the occurrence and development of hepatic fibrosis. In this paper, the relationship between leptin and the signaling pathways and molecules related to hepatic stellate cell activation in the occurrence and development of liver fibrosis is reviewed, in order to provide evidence for the treatment of hepatic fibrosis.

Key words: leptin, liver cirrhosis, hepatic stellate cells, signal transduction, activation, signaling pathways