The influencing factors and clinical diagnostic value of dry eye syndromes

doi:10.11958/20220589

Abstract

Abstract:

Objective To explore the influencing factors and clinical diagnostic value of dry eyes in patients with dry eye syndromes. Methods A total of 160 patients with dry eye were collected，including the mild dry eye group (n=51), the moderate dry eye group (n=61) and the severe dry eye group (n=48). Another 55 healthy subjects were selected as the normal control group. Data of the first tear film rupture time (NIBUTf), mean tear film rupture time (NIBUTav), tear film lipid layer thickness (LLT), lacrimal river height (LTMH) and conjunctival congestion score were detected by dry eye analyzer SLM-KD3. The ocular surface disease index (OSDI) scale score, corneal fluorescent staining score (FL) and tear secretion test (Slt) were performed in each group. Interleukin-17 (IL-17) and matrix metalloproteinase-9 (MMP-9) in tears were detected by enzyme-linked immunosorbent assay (ELISA). Univariate and multivariate Logistic regression were used to analyze influencing factors of dry eye. Results NIBUTf, NIBUTav, LLT, LTMH and SIt decreased in turn in the control group, the mild dry eye group, the moderate dry eye group and the severe dry eye group, while IL-17, MMP-9, OSDI and FL scores increased in turn (P<0.05). The score of conjunctival congestion was higher in the severe dry eye group than that in the control group and the mild dry eye group (P<0.05). Logistic regression analysis showed that higher levels of LLT and LTMH were protective factors for dry eyes, while higher levels of IL-17 and MMP-9 were risk factors for dry eyes. ROC analysis showed that when each individual index was diagnosed, the comprehensive advantage of LLT was more obvious, and the diagnostic specificity of IL-17 was higher, and the advantage of combined diagnosis of each index was the most obvious. Conclusion Higher levels of LLT and LTMH are protective factors for dry eyes, while higher levels of IL-17 and MMP-9 are risk factors for dry eyes. The combined detection of the four indexes is helpful in the diagnosis of dry eyes.

Key words: dry eye syndromes, early diagnosis, interleukin-17, matrix metalloproteinase 9, lipid layer thickness, lacrimal tear meniscus height

CLC Number:

R777.34

Figures/Tables 7

References 28

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组别	n	性别（男/女）	年龄（岁，$\bar{x}±s$）
对照组	55	23/32	56.78±9.33
轻度干眼组	51	17/34	54.14±7.92
中度干眼组	61	21/40	57.08±7.78
重度干眼组	48	22/26	55.08±10.29
χ²或F		2.345	1.360

组别	n	性别（男/女）	年龄（岁，$\bar{x}±s$）
对照组	55	23/32	56.78±9.33
轻度干眼组	51	17/34	54.14±7.92
中度干眼组	61	21/40	57.08±7.78
重度干眼组	48	22/26	55.08±10.29
χ²或F		2.345	1.360

组别		n	NIBUTf（s）		NIBUTav（s）		LLT（级）
对照组		55	10.52±1.14		12.44±1.12		4.62±1.01
轻度干眼组		51	7.33±1.98^a		8.47±1.08^a		3.37±0.96^a
中度干眼组		61	5.49±1.52^ab		6.71±1.82^ab		2.38±0.82^ab
重度干眼组		48	3.27±1.45^abc		3.19±1.10^abc		1.58±0.58^abc
F			206.558^＊＊		423.133^＊＊		121.520^＊＊
组别	LTMH （mm）			SⅠt （mm）		IL-17 （ng/L）		MMP-9 （μg/L）
对照组	0.23±0.09			11.81±2.08		66.25±8.93		37.75±8.18
轻度干眼组	0.17±0.07^a			8.45±2.45^a		79.83±12.68^a		44.28±5.16^a
中度干眼组	0.15±0.04^ab			5.48±1.89^ab		86.54±11.86^ab		49.46±11.94^ab
重度干眼组	0.12±0.03^abc			2.23±1.04^abc		93.16±10.31^abc		54.59±7.11^abc
F	33.295^＊			229.947^＊＊		57.238^＊		36.048^＊

组别		n	NIBUTf（s）		NIBUTav（s）		LLT（级）
对照组		55	10.52±1.14		12.44±1.12		4.62±1.01
轻度干眼组		51	7.33±1.98^a		8.47±1.08^a		3.37±0.96^a
中度干眼组		61	5.49±1.52^ab		6.71±1.82^ab		2.38±0.82^ab
重度干眼组		48	3.27±1.45^abc		3.19±1.10^abc		1.58±0.58^abc
F			206.558^＊＊		423.133^＊＊		121.520^＊＊
组别	LTMH （mm）			SⅠt （mm）		IL-17 （ng/L）		MMP-9 （μg/L）
对照组	0.23±0.09			11.81±2.08		66.25±8.93		37.75±8.18
轻度干眼组	0.17±0.07^a			8.45±2.45^a		79.83±12.68^a		44.28±5.16^a
中度干眼组	0.15±0.04^ab			5.48±1.89^ab		86.54±11.86^ab		49.46±11.94^ab
重度干眼组	0.12±0.03^abc			2.23±1.04^abc		93.16±10.31^abc		54.59±7.11^abc
F	33.295^＊			229.947^＊＊		57.238^＊		36.048^＊

组别	n	OSDI评分	结膜充血评分	FL评分
对照组	55	9.78±2.02	1.47±0.43	0.86±0.40
轻度干眼组	51	15.16±2.90^a	1.48±0.47	4.45±1.51^a
中度干眼组	61	23.72±3.29^ab	1.57±0.50	7.84±2.84^ab
重度干眼组	48	35.54±4.05^abc	1.72±0.61^ab	9.52±1.95^abc
F		656.595^＊＊	2.730^＊	210.755^＊＊