Research progress of influencing mechanism of COVID-19 on intestinal microbiota and related intestinal mucosal barrier defects

doi:10.11958/20220608

Abstract

Abstract:

The interaction between intestinal microbiota and intestinal mucosal barrier plays an important role in maintaining the stability of intestinal environment. Respiratory syndrome coronavirus infection can directly or indirectly disrupt the diversity of intestinal microflora through different ways, and affect the structure and metabolism of intestinal mucosal barrier. The intestinal homeostasis and microenvironment appear to play a major role in the pathogenesis of coronavirus disease 2019 (COVID-19) and the enhancement of the systemic inflammatory responses, suggesting that intestinal microbiota and mucosal barrier can be used as important therapeutic targets to reverse the pathological process of these patients. Therefore, this paper is a review about the research progress on the mechanism of COVID-19 induced intestinal microbiota and related intestinal mucosal barrier defects.

Key words: gastrointestinal microbiome, intestinal mucosal barrier, respiratory syndrome coronavirus 2, coronavirus disease 2019, systemic inflammatory responses, intestinal homeostasis and microenvironment

CLC Number:

R512.5，R373.1

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