The predictive value of serum CTRP3 and YKL-40 for implant prognosis in patients undergoing oral implant restoration

doi:10.11958/20241772

Abstract

Abstract:

Objective To investigate the predictive value of serum complement C1q tumor necrosis factor-related protein 3 (CTRP3) and chitinase protein-40 (YKL-40) in the prognosis of implants in patients with dentition defect after implant restoration. Methods A total of 98 patients with dentition defect were selected as the observation group, and 98 healthy people were selected as the control group. Based on the prognosis of the implant, patients were assigned into the good prognosis group (67 cases) and the poor prognosis group (31 cases). Enzyme linked immunosorbent assay was applied to detect serum levels of CTRP3 and YKL-40. Multivariate Logistic regression analysis was performed to analyze factors influencing the prognosis of implant defects. The receiver operating characteristic (ROC) curve was used to evaluate the efficacy of serum CTRP3 and YKL-40 levels in predicting implant prognosis. Results Compared with the control group, the serum CTRP3 level was prominently lower in the study group, and the serum YKL-40 level was prominently higher (P<0.05). Compared with the good prognosis group, the proportion of smoking patients and the serum YKL-40 level were prominently higher in the poor prognosis group, and the serum CTRP3 level was prominently lower (P<0.05). Elevated serum YKL-40 level and smoking history were risk factors for poor implant prognosis in patients, while elevated serum CTRP3 level was the protective factor (P<0.05). ROC curve analysis showed that the combination of serum CTRP3 and YKL-40 levels was superior to any single indicator in predicting the poor prognosis of implants in patients with dentition defect. Conclusion Serum CTRP3 level is decreased and serum YKL-40 level is increased in patients with dental defect, both of which are potential factors affecting poor implant prognosis. The combination of the two is more effective in predicting implant prognosis in patients with dental defect.

Key words: dental implants, complement C1q tumor necrosis factor related protein 3, chitinase protein-40, dental defect, oral implant restoration, prognosis

CLC Number:

R783.4

Figures/Tables 6

References 20

[1]	曹凯华, 黄伟坚. 慢性牙周炎合并牙列缺损患者行口腔种植修复技术治疗的近远期疗效分析[J]. 中国现代药物应用, 2021, 15(13):70-72.
	CAO K H, HUANG W J. Short-term and long-term effect of dental implant restoration in patients with chronic periodontitis and dentition defect[J]. Modern Pharmaceutical application in China, 2021, 15(13):70-72. doi:10.14164/j.cnki.cn11-5581/r.2021.13.024.
[2]	孙菲, 李思琪, 危伊萍, 等. 种植体周病非手术治疗中联合应用甘氨酸粉喷砂的临床效果评价[J]. 北京大学学报(医学版), 2022, 54(1):119-125.
	SUN F, LI S Q, WEI Y P, et al. Clinical evaluation of glycine powder air-polishing in non-surgical treatment of peri-implant diseases[J]. Journal of Peking University (Medical Edition), 2022, 54(1):119-125. doi:10.19723/j.issn.1671-167X.2022.01.019.
[3]	OGAWA T, SITALAKSMIi R M, MIYASHITA M, et al. Effectiveness of the socket shield technique in dental implant: A systematic review[J]. J Prosthodont Res, 2022, 66(1):12-18. doi:10.2186/jpr.JPR_D_20_00054.
[4]	邵雯婷, 张东. 即刻种植早期稳定性的影响因素及评价方法[J]. 中南大学学报(医学版), 2024, 49(2):305-311.
	SHAO W T, ZHANG D. Influencing factors and evaluation methods of early stability of immediate implant placement[J]. Journal of Central South University (Medical Edition), 2024, 49(2):305-311. doi:10.11817/.issn.1672-7347.2024.230244.
[5]	廖宏伟, 李学栋, 马金锋. 血清CTRP3及PGC-1α表达与创伤性骨折愈合的相关性分析[J]. 中国骨伤, 2022, 35(11):1059-1064.
	LIAO H W, LI X D, MA J F. Correlation analysis of serum CTRP3 and PGC-1α expression with traumatic fracture healing[J]. China Bone Injury, 2022, 35(11):1059-1064. doi:10.12200/j.issn.1003-0034.2022.11.010.
[6]	YOUNGSTROW D W, ZONDERVAN R L, DOUCET N R, et al. CTRP3 regulates endochondral ossification and bone remodeling during fracture healing[J]. J Orthop Res, 2020, 38(5):996-1006. doi:10.1002/jor.24553.
[7]	王冬梅, 袁宝军, 高利常, 等. CTD-ILD患者血清YKL-40和CCL18水平的变化及意义[J]. 天津医药, 2023, 51(2):198-202.
	WANG D M, YUAN B J, GAO L C, et al. Changes and significance of serum YKL-40 and CCL18 levels in patients with CTD-ILD[J]. Tianjin Med J, 2023, 51(2):198-202. doi:10.11958/20220567.
[8]	肖金庆, 孙芹芹, 霍金凤, 等. 血清YKL-40、Gal-3水平预测复发性口腔溃疡患儿治疗后复发的临床价值[J]. 标记免疫分析与临床, 2024, 31(5):849-854.
	XIAO J Q, SUN Q Q, HUO J F, et al. Clinical value of serum YKL-40 and Gal-3 levels in predicting recurrence of recurrent oral ulcer in children after treatment[J]. Label-based Immunoassay and Clinic, 2024, 31(5):849-854. doi:10.11748/bjmy.issn.1006-1703.2024.05.014.
[9]	张志愿, 周学东, 郭传殡, 等. 口腔科学[M]. 9版. 北京: 人民卫生出版社,2018:202-206.
	ZHANG Z Y, ZHOU X D, GUO C B, et al. Stomatology[M]. 9th ed. Beijing: People's Medical Publishing House,2018:202-206.
[10]	满毅, 于海洋, 王佐林, 等. 种植修复临床评价标准[J]. 华西口腔医学杂志, 2019, 37(1):1-6.
	MAN Y, YU H Y, WANG Z L, et al. Clinical evaluation criteria for implant restoration[J]. West China Journal of Stomatology, 2019, 37(1):1-6.
[11]	安应飞, 裴金莹, 郭莉, 等. 牙列缺失患者血清BGP、AKP、OPN水平与口腔种植修复术后种植体预后的关系[J]. 检验医学与临床, 2023, 20(15):2223-2227.
	AN Y F, PEI J Y, GUO L, et al. Serum levels of BGP,AKP and OPN in edentulous patients and their relationship with the prognosis of dental implants after implant restoration[J]. Lab Med & Clin, 2023, 20(15):2223-2227. doi:10.3969/j.issn.1672-9455.2023.15.019.
[12]	VAN OIRSCHOT B A J A, ZHANG Y, ALGHAMDI H S, et al. Surface engineering for dental implantology:favoring tissue responses along the implant[J]. Tissue Eng Part A, 2022, 28(11/12):555-572. doi:10.1089/ten.TEA.2021.0230.
[13]	霍花, 宋斌, 廖健. 种植体周病的相关信号通路机制及其交互调控作用[J]. 临床口腔医学杂志, 2024, 40(5):310-314.
	HUO H, SONG B, LIAO J. Mechanism of signal pathways related to peri-implant diseases and their interactive regulation[J]. J Clin Stomatology, 2024, 40(5):310-314. doi:10.3969/j.issn.1003-1634.2024.05.015.
[14]	ZOU C, TANG X, GUO T, et al. CTRP3 attenuates inflammation,oxidative and cell death in cisplatin induced HK-2 cells[J]. PeerJ, 2023, 11(1):e15890. doi:10.7717/peerj.15890.
[15]	LARSSON L, KAVANAGH N M, NGUYEN T V N, et al. Influence of epigenetics on periodontitis and peri-implantitis pathogenesis[J]. Periodontol, 2000,2022, 90(1):125-137. doi:10.1111/prd.12453.
[16]	QIN Y, ZHAO W. The modeling analysis and effect of CHI3L1 and CD31-marked microvessel density in the occurrence and development of cervical squamous cell carcinom[J]. Comput Math Methods Med, 2022,2022:3516335. doi:10.1155/2022/3516335.
[17]	BLAZEVIC N, ROGIC D, PELAJIC S, et al. YKL-40 as a biomarker in various inflammatory diseases: A review[J]. Biochem Med (Zagreb), 2024, 34(1):010502. doi:10.11613/BM.2024.010502.
[18]	TIZSOUI K, YANG J W, LEE K H, et al. The role of YKL-40 in the pathogenesis of autoimmune diseases: a comprehensive review[J]. Int J Biol Sci, 2022, 18(9):3731-3746. doi:10.7150/ijbs.67587.
[19]	肖金萍, 胥爱文, 王钟华, 等. 血清HSP27、YKL-40与侵袭性牙周炎患者Th17、Treg细胞的关系及对牙周-正畸联合治疗后预后的影响分析[J]. 现代生物医学进展, 2023, 23(14):2776-2780.
	XIAO J P, XU A W, WANG Z H, et al. The relationship between serum HSP27 and YKL-40 and Th17 and Treg cells in patients with aggressive periodontitis and its effect on the prognosis of patients after periodontal-orthodontic treatment[J]. Advances in Modern Biomedicine, 2023, 23(14):2776-2780. doi: 10.13241/j.cnki.pmb.2023.14.034.
[20]	辜义陆, 缪克红, 杨凤, 等. 血清CX3CL1、LTB4水平与牙列缺失患者口腔种植修复预后的关系[J]. 检验医学与临床, 2024, 21(16):2396-2405.
	GU Y L, MIAO K H, YANG F, et al. Relationship between serum CX3CL1 and LTB4 levels and the prognosis of dental implant restoration in edentulous patients[J]. Lab Med & Clin, 2024, 21(16):2396-2405. doi:10.3969/j.issn.1672-9455.2024.16.018.

组别	n	CTRP3/（ng/L）	YKL-40/（μg/L）
对照组	98	83.12±10.76	112.21±15.86
观察组	98	56.67±8.34	163.43±23.51
t		19.234^＊	17.879^＊

组别	n	CTRP3/（ng/L）	YKL-40/（μg/L）
对照组	98	83.12±10.76	112.21±15.86
观察组	98	56.67±8.34	163.43±23.51
t		19.234^＊	17.879^＊

组别		n		性别（男/女）		年龄/岁			经常摄入甜食（是/否）
预后良好组		67		41/26		39.12±8.76			29/38
预后不良组		31		17/14		39.86±8.53			11/20
χ²或t				0.354		0.391			0.534
组别	刷牙方式（正确/错误）						吸烟史（有/无）			饮酒史（有/无）
预后良好组	47/20						22/45			17/50
预后不良组	17/14						18/13			12/19
χ²	2.193						5.584^＊			1.809
组别			患牙部位
组别			前牙		磨牙			前磨牙			上、下颌牙
预后良好组			15（22.39）		11（16.42）			9（13.43）			32（47.76）
预后不良组			5（16.13）		4（12.90）			3（9.68）			19（61.29）
χ²			1.567
组别				缺损原因
组别				牙周病		牙体损伤			外伤
预后良好组				29（43.28）		28（41.79）			10（14.93）
预后不良组				14（45.16）		11（35.48）			6（19.35）
χ²				0.484

组别		n		性别（男/女）		年龄/岁			经常摄入甜食（是/否）
预后良好组		67		41/26		39.12±8.76			29/38
预后不良组		31		17/14		39.86±8.53			11/20
χ²或t				0.354		0.391			0.534
组别	刷牙方式（正确/错误）						吸烟史（有/无）			饮酒史（有/无）
预后良好组	47/20						22/45			17/50
预后不良组	17/14						18/13			12/19
χ²	2.193						5.584^＊			1.809
组别			患牙部位
组别			前牙		磨牙			前磨牙			上、下颌牙
预后良好组			15（22.39）		11（16.42）			9（13.43）			32（47.76）
预后不良组			5（16.13）		4（12.90）			3（9.68）			19（61.29）
χ²			1.567
组别				缺损原因
组别				牙周病		牙体损伤			外伤
预后良好组				29（43.28）		28（41.79）			10（14.93）
预后不良组				14（45.16）		11（35.48）			6（19.35）
χ²				0.484

组别	n	CTRP3/（ng/L）	YKL-40/（μg/L）
预后良好组	67	59.67±7.35	151.46±21.62
预后不良组	31	50.18±6.24	189.29±23.87
t		6.222^＊	7.793^＊