Abstract: Abstract：Through objective the zinc 、 IL-2、IL-10 content in serum and E2F1 in organization of cervical disease patients with the high-risk HPV infection,investigate it’s Clinical significance.Methods :Selected 130 cervical disease patients , including 30 CIN Ⅰ、30 CIN Ⅱ、20CIN Ⅲ and 20 cervical carcinoma with high-risk HPV infection, 30chronic cervicitis with HPV infection negetive. Detect Zn by Atomic absorption spectrometry and detected IL-2、IL-10 in their serum by ELISA. The expressions of E2F1 were detected by immunohistochemistry. Results:The content of Serum zinc、IL-2，in the CIN Ⅱ、CIN Ⅲand cervical cancer were decrease were all significantly(p<0.05);the content of IL-10，in the CIN Ⅲand cervical cancer were decrease were all significantly(p<0.05); the compare of the expression of E2F1 ，in the chronic cervicitis、the CIN and cervical cancer were all significantly(p<0.005).IL-2’s levels and zinc’s in serum was positively correlated（p<0.05), ,IL-2’s levels and IL-10 in serum was negatively correlated（p<0.05）, IL-2’s levels and E2F1’s in serum was negatively correlated（p<0.05 ）. Conclusion:In the high-level cervical disease and cervical cancer , occurred the drift of Thl to Th2, impact the clear of HPV . Zinc deficiency involved in this change. .

Key words: carcinoma, zinc, interleukin-2, interleukin-10, E2F1 transcription factor papillomavirideae, cervical intraepithelial neoplasia, uterine cervical neoplasms