Abstract: Abstract：Objective：To investigate the effect of the expression of VEGF 、vWF on vascular wall of Metabolic syndrome young rats . Methods：Four-week-old SD rats (50 g body weight) were randomly divided into 3 groups, routine diet group (NC), high fat diet group (FC) and high fat + high salt diet group (FSC). The values of body weight, abdominal circumference, blood pressure, visceral fat weight, plasma lipids, were measured 4 weeks after experiments. The levels of fasting plasma glucose and insulin were measured, and the insulin resistance index was calculated. HE stain and immunohistochemistry were used to detect the pathologic change and the infiltration cells with positive expression of VEGF，vWF in the abdominal aorta, Use elisa method to detect serum VEGF，vWF. Results: The values of body weight, abdominal circumference, blood pressure, visceral fat, plasma glucose and insulin level were significantly increased in the FSC group than that of the NC group. There were increased dyslipidemia and insulin resistance in the FSC group compared with those of the NC group. The abdominal aorta and serum express VEGF、vWF of FSC group were significantly increased than that of the NC，FC group. (p＜0.01). Conclusion: The rat model of metabolic syndrome was successfully established by high fat+salt diet in juvenile SD rats. The high expression of VEGF、vWF may be related to the occurrence and development of vascular pathology and physiological changes of metabolic syndrome in children.

Key words: metabolic syndrome, insulin resistance , VEGF , vWF , Vasculardisease models, animal , rats, Sprague-Dawley