Abstract:

[Abstract]   Objective   To investigate the effects of isotope labeled folate targeting albumin nanoparticles (
188Re-fo?late-CDDP/HAS MNP) on human SKOV3ovarian cancer cells in vivo.  Methods   The human SKOV3 ovarian cancer model was established in mice. Sixty-four tumor-bearing mice were randomly divided into eight groups: (A) negative control group,(B) chemotherapy group, (C) radiotherapy alone group, (D) hyperthermia alone group, (E) chemotherapy combined with radio?therapy group, (F) chemotherapy combined with hyperthermia therapy group, (G) radiotherapy combined with hyperthermia therapy group and (H) hyperthermia, chemotherapy and radiotherapy combined treatment group. After treatment, the cell proliferation and tumor growth were observed. The inhibitory rate of tumor mass was measured. The histopathological changes of tumor were observed in all groups.   Results   The quality of tumor was significantly lower in treatment groups than that of control group (P<0.05). There was the lowest quality of tumor in hyperthermia, chemotherapy and radiotherapy combined treatment group than that of other treatment groups (P<0.05).   Conclusion   The combination of magnetic induction hyper?thermia, chemotherapy, targeted radionuclide of radiation exposure can effectively inhibit the growth of ovarian cancer,which has the potential application for ovarian cancer treatment

Key words: cisplatin, folic acid, nanoparticles, albumins, ovarian neoplasms, carcinoma, radiotherapy, 透热疗法