Abstract:

[Abstract]  Objective  To investigate the correlation between Epstein-Barrvirus (EBV) and H.pylori (Hp) infection
and gastric cancer.  Methods  The EBV infection was examined by polymerase chain reaction (PCR) and in situ hybridization (ISH) in 100samples of gastric cancer tissue and82samples of gastritis tissue. The Hp infection was detected by PCR. The correlation between EBV and Hp infection and clinical and pathological features was analyzed in patients with gastric cancer.  Results  The positive rates of EBV and Hp were significantly higher in gastric cancer tissues than those in gastritis tissues (9.0%vs0and56.0%vs40.2%,P＜0.05). There was significantly higher infection rate in EBV in cardia gastric can-cer than that of gastric cancer (16.3%vs2.0%，P＜0.05). There were significantly higher infection rates in EBV and Hp in poorly differentiated carcinoma than those of well-differentiated carcinoma (15.7%vs2.0% and66.7%vs44.9%,P＜0.05). There were no significant differences in EBV and Hp infection between gender, age, nationality and lymph node metastasis (P＞0.05). There was no significant difference in Hp infection between different parts of gastric cancer. There was no correlation between EBV and Hp infection in gastric cancer tissues (r=0.137, P＞0.05).  Conclusion  EBV and Hp infection aretwo independent factors in the development of gastric cancer, and both of them are associated with the malignant evolution of gastric cancer.

Key words: helicobacter pylori, herpesvirus4, human, stomach neoplasms, carcinoma, helicobacter infections, ep-stein-barr virus infections, 爱泼斯坦巴尔病毒感染