Abstract:

[Abstract]   Objective   To investigate the relationship between matrix metalloproteinase-3(MMP-3) gene promoter
polymorphisms5A/6A and the restenosis after percutaneous coronary intervention (PCI).    Methods  A total of 437 patients with PCI were selected in this study. Patients were divided into mutant genotype group (5A/5A+5A/6A,n=136) and wild genotype group (6A/6A,n=301) according to MMP-3polymorphism. The angiography and clinic data were collected before and after coronary angiography in two groups of patients. The serum level MMP-3and genotype analysis were compared between two groups.    Results  There was no significant difference in the restenosis rate between two groups (42.2%vs33.1%,P＞0.05). The restenosis degree was significantly higher in wild genotype group than that in mutant genotype group (56.28%±11.10%vs36.00%±10.17%,P＜0.01). There was no significant difference in the serum level of MMP-3between two groups(13.38μg/L ±3.00μg/Lvs12.33μg/L±2.96μg/L,P＞0.05). There was a higher restenosis rate in patients carrying 6A allele than that of patients carrying 5A allele (P＜0.05). Carrying wild genotypes are risk factors for restenosis after PCI.   Conclusion   Patients carrying6A allele have significantly higher risk of resteonsis than patients carrying5A allele

Key words: matrix metalloproteinase-3, polymorphism, genetic, angioplasty, transluminal, percutaneous coronary, coronary restenosis