Abstract: Objective    To investigate the characteristics of serum oxidized low density lipoprotein(oxLDL) and traditional cardioascular risk factors of premature coronary atherosclerotic heat disease(PCAD)patients. Method    We continuously selected 70 PCAD patients who have accepted coronary artery interventional therapy and 60 patients with normal coronary artery confirmed by angiography to be control group, male patients in two groups were 31-55 years old and female patients were 42-65 years old. Compareted the levels of ox-LDL, high density lipoprotein cholesterol(HDL-C), triglyceride(TG), serum creatinine(SCr), uric acid(UA), C-reactive protein(CRP) and other serum biochemical indicators and the differences of general clinical materials in the two groups. Results     The PCAD group had significantly raised plasma levels at ox-LDL, TG, SCr,UA and percentage of male as compared with the contral group(P＜0.03), but significantly declined plasma level at HDL-C(P＝0.03) and there was no difference at the others indicators. There were positive correlations between UA,SCr and ox-LDL. The regression analysis showed: ox-LDL, HDL-C and SCr had significantly predictive value to PCAD, OR is 1.172、0.144、1.055 respectively. Conclusion    High levels of ox-LDL and SCr, and low levels of HDL-C are the independent predictors of PCAD.

Key words: Coronary diseases, lipoproteins, LDL, risk factors, oxidized low-density lipoprotein