Abstract: 【Abstract】 Objective To approach the effective therapy of the swell and necrosis in local skin and parenchyma by Chinese cobra snakebite. Methods The clinical data of 67 patients those all were bitten by Chinese cobra, were divided into three groups and were paved sulfadiazine silver,40%magnesium sulfate glycerol and jidesheng snake tablet respectively. Detumescence time and healing time were compared and analyzed. Results The mean detumescence time of group sulfadiazine silver,40%magnesium sulfate glycerol and jidesheng snake tablet were （8.82±1.92）days、（10.35±2.10）days and（11.42±2.61）days respectively, there were difference of statistical significance in the three groups (p<0.05).Compared by each two groups, there were both difference of statistical significance between the sulfadiazine silver group to the 40%magnesium sulfate glycerol group and the jidesheng snake tablet group (p<0.05),but there were no difference of statistical significance between the 40%magnesium sulfate glycerol group and the jidesheng snake tablet group (p>0.05).The mean healing time of group sulfadiazine silver,40%magnesium sulfate glycerol and jidesheng snake tablet were （17.45±6.67）days、（19.92±7.63）days and（20.74±8.50）days respectively. There were no difference of statistical significance in the three groups (p>0.05). Conclusions Treating the swell and necrosis in local skin and parenchyma by Chinese cobra snakebite, the efficacy of sulfadiazine silver was better than the 40%magnesium sulfate glycerol and jidesheng snake tablet at detumescence time, but there were no good and bad at healing time.

Key words: Chinese cobra, Swell, Necrosis, Therapy approach