Abstract: ABSTRACT Objective: To detect the ventricular synchronization in coronary heart disease patients with no heart failure sympathion and the effection of the combination with diabetes mellitus(DM) by Dopler tissue velocity imaging (TVI) technology. Methods: Selected127 cases of patients with coronary heart disease as the study group which was divided into groups with diabetes with coronary heart disease (CHD-DM group) and non-diabetic coronary heart disease (CHD-NG group). ⑴To measure and calculate the interventricular septum(IVS) and left ventricular posterior wall(LVPW) thickness, the left ventricular end systolic and diastolic diameter (LVEDs and LVEDd) and the volume (LVEVs and LVEVd), left ventricular ejection fraction(LVEF) . ⑵To measure time to peak velocity at systolic and early diastolic phase (Ts and Te) in the base and interlude altogether 14 segments of left and right ventricular in all subjects. To calculate and compare the average time of Ts and Te in left ventricular 12 segments (Ts-12-LV and Te-12-LV), the 12 segments standard deviation of Ts (Ts-12-SD) ,the 12 segmental maximal Ts and Te difference (Ts-12-diff and Te-12-diff) and the average time of Ts and Te in right ventricular 2 segments(Ts-2-RV and Te-2-RV). Results: 1. The Ts in 11 segments of left ventricular, Ts-12-LV, Ts-2-RV, Ts-2-RV and Ts-12-diff were failed to demonstrate any statistically significant differences between CHD-DM group and CHD-NG group (p＞0.05). by the Ts-12-SD＞33 ms as the standard , CHD-DM group who achieve this standard were 17 cases, 11 cases of the control group. To Ts-12-diff＞100 ms as the standard, the ratio of the two groups were 50%(34/68) and 28.8%(17/59), p＜0.01. the Te-12-diff were also failed to demonstrate any statistically significant differences between the two group(p＞0.05)，but under the standard of Te-12-diff＞100 ms, the two groups accounted for 47.1% and 25.4% (p＜0.01). 2.In the CHD-DM group Vs and Ve in most segments of left and right ventricular were lower than that of CHD-NG group, especially in group of CHD-DM and CRBBB(p＜0.05 or p＜0.01). Conclusion: The Ts-12-diff and Te-12-diff in patients with coronary heart disease who didn’t have symptoms of heart failure and unnormal QRS duration were significantly longer, especially in patients who had coronary heart disease with diabetes mellitus, suggesting that the systolic and diastolic synchronization was reduce in patients with coronary heart disease, diabetes can increase it.

Key words: Dopler tissue velocity imaging, Coronery heart disease, Diabetes mellitus, Cardiac synchronization