Abstract: Abstract Objective: To study the Correlations with CRP, IL-6 and the severity of stenosis of coronary artery. Methods: 120 patients undergoing quantitative coronary angiography were involved in this study, and we measured the titer of CRP and IL-6. The severity scale of coronary artery stenosis was quantitatively assessed according to coronary angiography by Gensini score. The patients were categorized into control group and CAD group The CAD patients were classified to1, 2 and 3-vessel-lesion group according to the results of Angiography. Results: The CAD group had higher titers of CRP and IL-6 than the control group. In muiltvariate analysis, CRP and IL-6 were demonstrated to be independent risk factors. Neither CRP nor IL-6 were along with the number of lesion-vessels. In the correlation analyses, Gensini were significantly associated with IL-6, but neither CRP nor IL-6 were independent risk factors of Gensini score. Conclusion: CRP and IL-6 have correlation with CAD and are demonstrated to be significant predictors of CAD. But, nither CRP nor IL-6 are correlated with severity of CAD assessed by coronary angiography.

Key words: CRP, IL-6, Gensini score, Coronary heart disease, Coronary artery angiography