Abstract: Abstract Objective : Through detecting the expression of CD8,CD20, Interleukin-6 and Interleukin-23 in tissue of benign prostatic hyperplasia, evaluate the effect of immune-inflammation in the development and progression of BPH . Methods : Collect the medical records and specimens of 60 BPH patients treated by operation. Immunohistochemical analysis were used to examine the expression of CD8,CD20, Interleukin-6 and Interleukin-23 in BPH tissues. Results : 50 cases (83%) had CD8 as T-lymphocytes markers , 36 cases (60%) had CD20 as B-lymphocytes markers, 47cases(78%) had Interleukin-6 and 33 cases (55%) had Interleukin-23. The group of all cytokines are vivid positive had higher prostate volume and IPSS scores than the negative group (P<0.01). Conclusions : Inflammatory cell markers and inflammatory factors infiltrate the tissue of BPH,and had strong correlation with the clinical data. We can suppose that immune-inflammation may play an important role in the development and progression of BPH.

Key words: BPH, CD8, CD20, Interleukin-6, Interleukin-23.