Abstract: Objective: To investigate the role of MitoKATP in rats with SAP and its mechanism of myocardial protection. Methods: 36 healthy SD rats were randomly divided into 4 groups: K group was given sham operation; M group was established SAP model in rats; Respectively consecutive intraperitoneal injection of DZ and DZ+ 5-HD for 3 days,D and H groups were made to SAP model too. Detected the levels of serum CK-MB and LDH at 24 hours after the operation.Applied Spectrophotometry to detect Na+-K+-ATPase activity of myocardial tissue.The alteration of mitochondrial membrane potential was detected by flow cytometry.The technique of TUNEL was used to detect myocardial apoptosis. Heart and pancreas was stored to perform histopathologic examination. Results: Compared with the D group,the levels of serum CK-MB and LDH,the heart pathological scores and the myocardial apoptosis index were higher in M group (P<0.01),while the Na+-K+-ATPase activity and mitochondrial membrane potential decreased in M group(P<0.01)。But there were no significant difference with Mand H group（P>0.05）. Conclusion: Opening MitoKATP Channel had myocardial protective effect in Rats with SAP.

Key words: MitoKATP, Severe acute pancreatitis, rats, myocardial protection