Abstract: Objective To evaluate the correlation of Omentin-1 , the high sensitivity C-reactive protein(hsCRP) and coronary heart disease (CHD) by test the serum level of them. Methods Sixtyeight patients with CHD were divided into the unstable angina pectoris (UAP) group (n =36) and the stable angina pectoris (SAP) group (n=32), 30 normal subjects without CHD diagnosed by coronary arteriography(CAG) served as the control group. The serum level of Omentin-1 is measured by enzyme linked immune sorbent assay (ELISA) and the serum level of hsCRP is measured by turbidmetric immunoassay. Results The serum level of Omentin-1 were lower in UAP and SAP group than control group (P<0.05). The serum level of hsCRP were higher in UAP and SAP group than control group (P<0.05).The mean level of hsCRP in UAP group was differently significantly, compared with that in SAP (P>0.05) .While the Omentin-1 is the opposite. The mean level of Omentin-1 in single, double and three vessel lesion group were lower than that in control group (F＝22.02，P<0.05) .The mean level of hsCRP in single, double and three vessel lesion group were higher than that in control group (F＝19.78，P<0.05), but the serum levels of Omentin-1or hsCRP among single, double and three were not significant different (P>0.05). The serum level of Omentin-1and hsCRP were significantly negative correlation in Spearman correlation coefficients (r＝-0.543,P＜0.01). Conclusions Omentin-1 and hsCRP may correlate with CHD. However, may not reflect the severity of artery stenosis.

Key words: Omentin-1, High sensitive C-reactive protein, Coronary heart disease, Angina pectoris, Arteriosclerosis